Genetics may help explain why results from weight-loss jabs vary, say scientists

Scientists have discovered that variations in two specific genes may explain why weight-loss jabs, particularly GLP1 medicines, work differently for individuals. Analyzing data from almost 28,000 patients, researchers found these genetic differences in gut hormone pathways, which regulate appetite and digestion. These variations can account for different weight-loss outcomes or side effects experienced by patients. This significant finding offers a genetic basis for the varying efficacy of current obesity treatments. Ultimately, understanding these gene variations could lead to more personalized and improved therapeutic strategies for managing obesity.